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#4 Science HQ » Malaria » Today 16:00:11

Jai Ganesh
Replies: 0

Malaria

Gist

Malaria is a severe, often fatal, disease caused by Plasmodium parasites transmitted through the bites of infected female Anopheles mosquitoes, primarily in tropical regions. Symptoms include high fever, shivering chills, headache, and fatigue. It is preventable and curable, but requires prompt diagnosis and treatment.

Malaria is caused by single-celled Plasmodium parasites, which are transmitted to humans through the bite of an infected female Anopheles mosquito. When an infected mosquito bites a person, the parasites enter the bloodstream, travel to the liver to mature, and subsequently infect red blood cells, causing symptoms.

Summary

Malaria is a mosquito-borne infectious disease which is transmitted by the bite of Anopheles mosquitoes. Human malaria causes symptoms that typically include fever, fatigue, vomiting, and headaches; in severe cases, it can cause jaundice, seizures, coma, or death. Symptoms usually begin 10 to 15 days after being bitten by an infected Anopheles mosquito. If not properly treated, people may have recurrences of the disease months later. Those who survive an infection develop partial immunity, being susceptible to reinfection although with milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria.

Malaria is caused by single-celled parasites of the genus Plasmodium, generally spread through the bites of an infected female Anopheles mosquito. The mosquito bite introduces the parasites from the mosquito's saliva into the blood. The parasites initially reproduce and mature in the liver without causing symptoms. After a few days the mature parasites spread into the bloodstream, where they infect and destroy red blood cells, causing the symptoms of infection. Five species of Plasmodium commonly infect humans. The three species associated with more severe cases are P. falciparum (which is responsible for the vast majority of malaria deaths), P. vivax, and P. knowlesi (a simian malaria that spills over into thousands of people a year). P. ovale and P. malariae generally cause a milder form of malaria. Malaria is typically diagnosed by the microscopic examination of blood using blood films, or with antigen-based rapid diagnostic tests. Methods that use the polymerase chain reaction to detect the parasite's DNA have been developed, but they are not widely used in areas where malaria is common, due to their cost and complexity.

The risk of disease can be reduced by preventing mosquito bites through the use of mosquito nets and insect repellents or with mosquito-control measures such as spraying insecticides and draining standing water. Several prophylactic medications are available to prevent malaria in areas where the disease is common. As of 2023, two malaria vaccines have been endorsed by the World Health Organization. Resistance among the parasites has developed to several antimalarial medications; for example, chloroquine-resistant P. falciparum has spread to most malaria-prone areas, and resistance to artemisinin has become a problem in some parts of Southeast Asia. Because of this, drug treatment for malaria infection should be tailored to best fit the Plasmodium species involved and the geographical location where the infection was acquired.

The disease is widespread in the tropical and subtropical regions that exist in a broad band around the equator. This includes much of sub-Saharan Africa, Asia, and Latin America. In 2023, some 263 million cases of malaria worldwide resulted in an estimated 597,000 deaths. Around 95% of the cases and deaths occurred in sub-Saharan Africa. Malaria is commonly associated with poverty and has a significant negative effect on economic development; in Africa, it is estimated to result in economic losses (estimated at US$12 billion a year in 2005) due to increased healthcare costs, lost ability to work, and adverse effects on tourism.

Details

Malaria is a potentially life-threatening illness caused by parasites. You get it through the bite of an infected mosquito. It’s most common in parts of the world that are hot and humid, like Africa and parts of Asia. It can cause flu-like symptoms that can progress to severe illness if not treated.

What Is Malaria?

Malaria is a disease you get from being bitten by a mosquito. Some mosquitoes carry tiny parasites. They can infect you with the parasites when they bite you. Malaria can cause severe illness and death if left untreated. Kids under 5 are more likely to get life-threatening illness. Malaria is most common in tropical areas where it’s hot and humid. Most cases happen in Africa. It’s rare in the U.S. See a healthcare provider right away if you live in or have traveled to an area where malaria spreads and you have symptoms. This is true even if you’ve taken medications to prevent malaria during your trip.

Symptoms and Causes:

Symptoms of malaria

Symptoms of malaria can be mild to severe. They often start as flu-like symptoms and can get worse. They include:

* Fever
* Chills
* Headache
* Muscle aches
* Fatigue
* Difficulty breathing
* Diarrhea, nausea or vomiting
* Seizures
* Yellowing of your skin or whites of your eyes (jaundice)
* Dark or bloody pee

Malaria symptoms usually appear several days to a month after you’re infected. Some people don’t feel sick for a year or longer after the mosquito bite.

Malaria causes

Plasmodium parasites cause malaria. There are five types that can infect humans. Plasmodium falciparum (P. falciparum) and Plasmodium vivax (P. vivax) are the most common. P. falciparum often causes severe illness.

How do you get malaria?

A mosquito gets the parasitic infection when it bites someone who’s infected. The mosquito then bites you and spreads the infection. The parasite multiplies in your liver and spreads to your bloodstream. There, it can spread to other people if a mosquito bites you. Rarely, malaria can also spread through:

* Pregnancy or childbirth (vertical transmission)
* Blood transfusions
* Organ donations
* Sharing needles

Risk factors

You’re at a higher risk of getting malaria if you live in or travel to areas where it spreads, like parts of Africa. You’re at a higher risk of serious illness and death if you:

* Are younger than 5
* Are pregnant
* Have a weakened immune system
* Don’t have access to healthcare

What countries have malaria?

Malaria is most common in areas with warm temperatures and high humidity, including:

* Africa
* Central and South America
* Dominican Republic, Haiti and other areas in the Caribbean
* Islands in the Central and South Pacific Ocean (Oceania)
* South and Southeast Asia

Complications of malaria

If left untreated, malaria can cause severe complications. These include:

* Blocked blood vessels in your brain (cerebral malaria)
* Coma
* Organ failure

These complications can be fatal.

Diagnosis and Tests:

How doctors diagnose malaria

Healthcare providers test a sample of your blood to diagnose malaria. They’ll look for Plasmodium parasites and identify what type of infection you have. Your provider will use this information to determine the right treatment. It’s important to tell your provider if you’ve traveled within the past year so they know to test for malaria.

Management and Treatment:

How is malaria treated?

Healthcare providers treat malaria with medications that kill the parasite (antimalarial medications). The type of antimalarial medication your provider treats you with depends on:

* Where you were infected — you’re more likely to get drug-resistant infections in certain parts of the world
* The type of Plasmodium causing the infection
* How sick you are
* Whether you’re pregnant or breastfeeding
* Your age

Medications can cure malaria, but it’s important to start treating it as soon as possible.

Antimalarial drugs

Antimalarial medications kill the Plasmodium parasites. You might receive them in an IV or take them by mouth. They include:

* Artemether-lumefantrine
* Atovaquone-proguanil
* Chloroquine or hydroxychloroquine
* Doxycycline, tetracycline or clindamycin
* Mefloquine
* Quinine
* Primaquine
* Tafenoquine

You might receive one or a combination of these. Take all medications as prescribed, even if you start to feel better.

When should I see my healthcare provider?

See a healthcare provider right away if you’ve traveled to or live in a country where malaria is common and you have symptoms. Early diagnosis gives you the best chance for a full recovery.

Outlook / Prognosis:

What can I expect if I have malaria?

Antimalarial medications can cure malaria, especially if started early. You might need to stay at the hospital, at least to start your treatment. Treatment can last for about two weeks, but you might start feeling better in a few days. Let your provider know if you aren’t feeling better or if your symptoms get worse. Sometimes, even after treatment, malaria infections can come back (recur). This happens when the parasite isn’t completely killed by treatment. It can stay in your body without causing symptoms. You can start having symptoms again years after your initial infection and treatment. Medications like primaquine and tafenoquine make this less likely to happen. You can get malaria again, even if you’ve had it before.

Prevention:

Can you prevent malaria?

There are a few ways to reduce your risk of getting and spreading malaria:

* Preventive medications: If you’re traveling to an area where malaria is common, your healthcare provider might prescribe antimalarial medications for you to take before, during and after your stay. If you get malaria while on an antimalarial drug, providers will give you a different medication to treat it.
* Mosquito bite prevention: Wear bug spray with DEET, cover as much skin as possible with clothing, sleep under mosquito netting and take other precautions to avoid getting bitten.
* Vaccination: Public health officials recommend vaccinating against malaria for children who live in areas where infections are common. They’re not currently recommended for travelers.

Additional Information:

Overview

Malaria is a disease caused by a parasite. The parasite is spread to humans through the bites of infected mosquitoes. People who have malaria usually feel very sick with a high fever and shaking chills.

While the disease is uncommon in temperate climates, malaria is still common in tropical and subtropical countries. Each year nearly 290 million people are infected with malaria, and more than 400,000 people die of the disease.

To reduce malaria infections, world health programs distribute preventive drugs and insecticide-treated bed nets to protect people from mosquito bites. The World Health Organization has recommended a malaria vaccine for use in children who live in countries with high numbers of malaria cases.

Protective clothing, bed nets and insecticides can protect you while traveling. You also can take preventive medicine before, during and after a trip to a high-risk area. Many malaria parasites have developed resistance to common drugs used to treat the disease.

Symptoms

Signs and symptoms of malaria may include:

* Fever
* Chills
* General feeling of discomfort
* Headache
* Nausea and vomiting
* Diarrhea
* Abdominal pain
* Muscle or joint pain
* Fatigue
* Rapid breathing
* Rapid heart rate
* Cough

Some people who have malaria experience cycles of malaria "attacks." An attack usually starts with shivering and chills, followed by a high fever, followed by sweating and a return to normal temperature.

Malaria signs and symptoms typically begin within a few weeks after being bitten by an infected mosquito. However, some types of malaria parasites can lie dormant in your body for up to a year.

When to see a doctor

Talk to your doctor if you experience a fever while living in or after traveling to a high-risk malaria region. If you have severe symptoms, seek emergency medical attention.

Complications

Malaria can be fatal, particularly when caused by the plasmodium species common in Africa. The World Health Organization estimates that about 94% of all malaria deaths occur in Africa — most commonly in children under the age of 5.

Malaria deaths are usually related to one or more serious complications, including:

* Cerebral malaria. If parasite-filled blood cells block small blood vessels to your brain (cerebral malaria), swelling of your brain or brain damage may occur. Cerebral malaria may cause seizures and coma.
* Breathing problems. Accumulated fluid in your lungs (pulmonary edema) can make it difficult to breathe.
* Organ failure. Malaria can damage the kidneys or liver or cause the spleen to rupture. Any of these conditions can be life-threatening.
* Anemia. Malaria may result in not having enough red blood cells for an adequate supply of oxygen to your body's tissues (anemia).
* Low blood sugar. Severe forms of malaria can cause low blood sugar (hypoglycemia), as can quinine — a common medication used to combat malaria. Very low blood sugar can result in coma or death.

Malaria may recur

Some varieties of the malaria parasite, which typically cause milder forms of the disease, can persist for years and cause relapses.

Prevention

If you live in or are traveling to an area where malaria is common, take steps to avoid mosquito bites. Mosquitoes are most active between dusk and dawn. To protect yourself from mosquito bites, you should:

* Cover your skin. Wear pants and long-sleeved shirts. Tuck in your shirt, and tuck pant legs into socks.
* Apply insect repellent to skin. Use an insect repellent registered with the Environmental Protection Agency on any exposed skin. These include repellents that contain DEET, picaridin, IR3535, oil of lemon eucalyptus (OLE), para-menthane-3,8-diol (PMD) or 2-undecanone. Do not use a spray directly on your face. Do not use products with oil of lemon eucalyptus (OLE) or p-Menthane-3,8-diol (PMD) on children under age 3.
* Apply repellent to clothing. Sprays containing permethrin are safe to apply to clothing.
* Sleep under a net. Bed nets, particularly those treated with insecticides, such as permethrin, help prevent mosquito bites while you are sleeping.

Preventive medicine

If you'll be traveling to a location where malaria is common, talk to your doctor a few months ahead of time about whether you should take drugs before, during and after your trip to help protect you from malaria parasites.

In general, the drugs taken to prevent malaria are the same drugs used to treat the disease. What drug you take depends on where and how long you are traveling and your own health.

Vaccine

The World Health Organization has recommended a malaria vaccine for use in children who live in countries with high numbers of malaria cases.

Researchers are continuing to develop and study malaria vaccines to prevent infection.

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#5 Re: This is Cool » Miscellany » Today 00:04:13

2524) Microchip

Gist

Microchips (integrated circuits) are tiny silicon devices containing millions or billions of transistors that process, store, and manage data within electronics. They act as the "brains" or "nervous system" for devices ranging from smartphones and computers to cars, medical devices, and household appliances.

Microchips, also known as integrated circuits or computer chips, are the tiny, powerful devices at the heart of nearly every device we use today. These chips are essential building blocks in all modern technology: from smartphones and computers to cars and medical devices.

Summary

Microchips, those unassuming slivers of silicon, are more than just components; they are the linchpins of modern technology. Fundamentally, a microchip, or an integrated circuit, is a convergence of numerous electronic elements—transistors, resistors, capacitors—meticulously integrated onto a tiny silicon chip. This integration represents more than just a triumph in making things smaller; it stands as a powerful demonstration of human creativity and skill in the field of electronics.

The true value of microchips lies not in their physical form but in their pervasive influence across various technological domains. From the smartphone in your pocket to the satellites orbiting our planet, microchips are the unsung heroes, silently orchestrating the digital symphony that underpins our daily lives.

As we delve into the workings of microchips, this article aims to transcend the fleeting trends of the tech world, focusing instead on the enduring principles that make microchips a cornerstone of innovation. We'll explore their fundamental concepts, steering clear of ephemeral specifics, to appreciate their lasting impact on technology.

Details

A microchip is an electronic device made of a small, flat piece of semiconductor material modified with other dopants, oxides, and metals to create electronic components, including transistors, diodes, resistors, and capacitors connected in a circuit.

Microchips are also called:

* Integrated circuits (ICs)
* Computer chips
* Semiconductors
* Chips

Integrated circuits have replaced assemblies of discrete components attached by wires or printed circuit boards (PCBs) because they are a single monolithic device that is much smaller, uses much less power, and can be mass produced at a significantly lower cost.

Semiconductor materials were discovered in 1821 by Thomas Johann Seebeck, and the first working semiconductor transistors were created by Willam Shockley in 1947. The components and all their interconnects were then combined into a single device in 1959 by Robert Noyce. The key to this invention and all that followed was the planar manufacturing process, which used photolithography to deposit and remove materials one layer at a time in a precise manner.

Integrated circuits are an integral part of modern life, providing electronics for devices ranging from toys to deep space probes. In 2023, the worldwide revenue from microchip sales was $526.9 billion. That year’s sales also saw further growth in chip usage beyond computers: 32% were for communication, 17% for automotive applications, 14% for industrial devices, 11% for consumer electronics, and only 25% for computing.

Driven by Moore’s Law, which states that the number of transistors in an IC will double every two years, the growing complexity of the circuits and the ever-decreasing size of components make designing and manufacturing microchips more challenging with each generation of chips.

The general size of individual elements on a chip, referred to as feature size, is measured in nanometers (nm), or one-billionth of a meter. Current semiconductor manufacturers use 14-nm, 10-nm, 7-nm, 5-nm, and 3-nm processes, with 2-nm technologies coming online. For scale, a grain of rice is 5 million nanometers long.

In 2023, researchers created a record-breaking microprocessor containing 1.2 trillion transistors. Intel’s line of CPUs in 2024 include more than 100 million transistors on a single chip.

The Elements of a Typical Microchip

Integrated circuits are made from semiconductor material, usually silicon, stacked in overlapping layers. Here are the most common elements in a microchip:

* Silicon substrate: The base pure silicon crystal layer from which the other layers are constructed by removing or depositing other materials or doping the crystal material.
Silicon Wafer
* Layers: Electronic circuits are created on individual layers. Layers are modified with photolithography, etching, and deposition to produce the desired components and interconnections. Some layers also serve as electrical insulators.
* Vias: A conducting zone, usually cylindrical, used to transmit electrical signals between layers.
* Components: The electronic devices that make up the desired circuit. In most ICs, these consist of transistors, capacitors, diodes, resistors, and sometimes inductors.
* Interconnects: Metalized paths on a given layer that conduct electricity between components or to vias.
* Packaging: Once completed, the IC is placed inside an assembly called a semiconductor package that protects and insulates the delicate silicon chip, can connect multiple chips, and provides a way to connect the chip or chips to a larger electronics circuit.

How Microchips Are Manufactured

There are three steps to microchip manufacturing. Each step is highly optimized and automated to minimize cost, ensure quality, and maximize efficiency. Engineers designing ICs need to have a good understanding of the manufacturing process because each step determines the size, shape, and spacing of the components.

Step 1: Wafer Production

Making blank silicon wafers is the first step in semiconductor manufacturing. This process begins by growing a monocrystalline cylindrical ingot, called a boule, of semiconductor material, usually pure silicon. The boule is then sliced into a thin wafer, machined to create a flat surface, chemically etched to remove any damage from the machining, and polished. Electronic wafers are usually 100 to 450 mm in diameter. The most common size is 300 mm across and 755 µm thick.

Step 2: Fabrication

The circuitry, with all its components and interconnects, is created in a semiconductor fabrication facility, usually called a fab. Each layer and the topology of the circuitry is created in a series of highly controlled steps. Robots move wafers from machine to machine in clusters. Most chip fabrication processes follow these steps for each layer:

* Grow a silicon dioxide layer to cover the layer completely (also called passivation).
* Add a photoresist coating.
* Expose the photoresist layer to ultraviolet light in the pattern of the geometry you want to create. The photoresist layer is then developed, and the material exposed to light is removed. This is called photolithography.
* Use chemicals, usually a strong acid, to remove the oxide layer where the photoresist was removed. This is referred to as etching.
* Remove the undeveloped photoresist material.
* If doping is needed for the layer, ion implantation of contaminants into the crystal structure creates the desired semiconductor behavior for transistors and other components.
* For other materials, various forms of chemical or vapor deposition are used to create interconnects, vias, and other components.

Step 3: Packaging

Once each layer has been constructed and the wafer is cleaned and tested, it is cut into individual chips called dies. One or more dies are then attached to a structure through bonding, and the IC is encapsulated in different materials, depending on the application. Some packages contain a single chip, but the current trend is to combine multiple dies in a single package.

Microchip Types and Uses

The types and uses of integrated circuits are growing every year. Early ICs often performed a single function. But as the manufacturing technology and design tools have improved, chips have shifted to being multifunction.

Smartphones are a great example of how multiple types of chips can be combined in a single device for different uses. They contain radio frequency (RF) chips for the 5G radio and GPS, optoelectrical chips for the cameras, LED chips for the display, digital ICs for the processing units, micro-electromechanical systems (MEMS) chips for the accelerometer, and a dozen other integrated circuits to sense, control, and modify a vast number of uses.

The different types of chips can be categorized by the signaling they carry out.

Analog Integrated Circuits

Analog signals carry voltage across a continuous voltage range, not just a high or a low voltage signal. They are used to amplify, filter by frequency, and mix signals. The frequency and power of an analog IC can vary greatly, and higher frequencies and higher powers present significant design challenges.

Common uses for analog ICs include:

* Optical, thermal, and audio sensors
* Power management circuits
* Operational amplifiers (op-amps)
* Audio and video signal processing
* Telecommunications, including radio communication and optical signal processing
* RF circuits
* Signal conditioning
* Machine controllers

Digital Integrated Circuits

Digital ICs are logic devices that contain millions or billions of logic gates made of transistors. A signal running at a fixed clock frequency is modified or measured as either high or low, zero or one. By combining different logic devices, very complex calculations can be done with very little power used.

Some of the most common uses for digital ICs include:

* Logic ICs or processors
** Microprocessors
** Microcontrollers
** Application-specific integrated circuits (ASICs)
* Memory chips
* Field programmable gate arrays (FPGAs)
* Digital power management devices
* System-on-a-chip (SoC) devices
* Multi-die chips

Mixed-signal Integrated Circuits

Some integrated circuits combine circuitry to handle analog and digital signals and convert between the two to create mixed-signal integrated circuits. They are used when an analog signal is sensed or created and logical operations are needed to read, create, or modify that signal.

Some of the most common uses for mixed-signal ICs are:

* SoC devices
* Data acquisition chips
* RF CMOS circuits
* Clock/timing ICs
* Switched capacitor circuits
* Electro-optical devices
* MEMS devices

Future Trends in Microchip Technology

The future of microchips looks like the past, with more capabilities in smaller sizes while constantly driving the cost down. Advances in manufacturing will also create new opportunities for better performance and new applications.

Trends that will drive electrical engineering design and simulation in the near future include:

Shift to Fabless Design and Foundries

The industry has shifted over the years to a model where companies can design their own ICs and then outsource the manufacturing to a company that just makes chips. This is called fabless design, and the contract manufacturers are called foundries. This enables companies like Apple and Qualcomm to design innovative new products without the capital investment of building their own fabrication facilities. Engineers must design to the manufacturing processes and standards of the foundry they will use.

Smaller Feature Size

Feature sizes continue to shrink, creating power and signal integrity issues. To stay competitive, electrical engineers need to design using these new capabilities, as well as leveraging simulation and design best practices to avoid issues.

Electronic Device Complexity and Combined Functionality

With time, an increasing number of designers of electronic devices are looking for greater functionality in a single chip. Internet of Things (IoT) devices, new solid-state long-term storage, and GPU chips are examples of integrated circuits that will not only add new features and capabilities in the same chip, but the interaction between those functions will also become more sophisticated. Engineers need design and simulation tools to drive designs in which the industry is pulling the technology. Biomedical electronics like implanted microchips will be another area in which several capabilities are needed on a single chip.

Higher Clock Speeds and Frequencies

Increased performance demands and advances in RF technology are driving up clock speeds for digital ICs and frequencies for analog and mixed-signal chips. Both create issues with signal integrity and power management.

Greater Computer Power With Increased Energy Efficiency

The growth of data centers for high-performance computing to support trends like artificial intelligence, cryptocurrency mining, and IoT applications is driving demand for increased performance for microprocessors. These applications are pushing the industry for improvements in FPGAs, solid-state hard drives, memory, and GPUs, along with all the chips needed to connect everything at increasing data transfer speeds.

More Use Beyond Computing

The trend of increased microchip use in automotive, consumer electronics, and industrial applications will continue. Almost all products will be designed as smart devices with connectivity to broadband, sensors, and computing power — all of which need microchips.

Simulation in the Design of Microchips

The complexity and expense of microchip manufacturing make physically prototyping designs impractical. Instead, engineers use virtual prototyping through simulation to drive their design, verify the performance, and identify and solve problems before production begins. Simulation is also used to design packaging and optimize the semiconductor manufacturing machines that make the chips.

Using simulation for digital microchips begins with verifying the logical functionality of the digital design at an abstract level with RTL design. This includes a first look at power management with PowerArtist™ software. This tool can assess the power needs of a design early in the process and help drive a more power-efficient design.

Once the physical design is laid out, engineers can use RedHawk-SC™ software, the trusted industry leader for power noise and reliability for digital ICs, to assess voltage drop and electromigration in their designs.

On the analog and mixed-signal side of things, Totem™ software can be brought into the process for power integrity and reliability signoff. The industry’s trusted gold standard for electromigration multiphysics, it is certified by all major foundries down to 3 nm. It also works with PathFinder-SC™ software to calculate electrostatic discharge.

Once the design is optimized and verified, packaging engineers can use simulation to optimize the power, signal integrity, and robustness of the full microchip package. RedHawk-SC software is designed to handle large, multichip configurations, including system-in-package designs. Advanced semiconductor packaging uses 2.5D- and 3D-IC approaches to combine and connect multiple dies in the same package, and simulation with RedHawk-SC software is the primary way to verify and optimize the designs.

Once the electrical aspects of the design are resolved, packaging engineers can use tools like Mechanical™software and the Icepak® tool for structural reliability and thermal management.

Additional Information:

What is a microchip?

A microchip -- also called a chip, computer chip or integrated circuit (IC) -- is a unit of integrated circuitry that is manufactured at a microscopic scale using a semiconductor material, such as silicon or, to a lesser degree, germanium. Electronic components, such as transistors and resistors, are etched into the material in layers, along with intricate connections that link the components together and facilitate the flow of electric signals.

Microchip components are so small they're measured in nanometers (nm). Some components are now under 10 nm, making it possible to fit billions of components on a single chip. In 2021, IBM introduced a microchip based on 2 nm technology, smaller than the width of a strand of human DNA. A nanometer is one-billionth of a meter or one-millionth of a millimeter. At that scale, it is possible to fit up to 50 billion transistors on a microchip the size of a fingernail.

How are microchips made?

Microchip manufacturers rely on silicon for their chips because it is abundant, inexpensive and easy to work with. Also, it has proven to be a reliable semiconductor in a variety of devices. However, silicon might be reaching its practical limits as microchip technologies become smaller and more components are squeezed into the microchip in an effort to meet the ever-increasing demands for greater performance and more data. Researchers are actively working on a variety of solutions that they hope will be able to carry electronics into the future.

Microchips typically include the following types of components, which can number into the millions or even billions, depending on the type and function of the microchip:

* Transistors. Transistors are active components that control, generate or amplify electric signals within the circuitry, acting as a switch or gate. Multiple transistors can be combined into a single logic gate that compares input currents and produces a single output according to the specified logic.
* Resistors. Resistors are passive components that limit or regulate the flow of electrical current or that provide a specific voltage for an active device. Resistors control the electric signals that move between transistors.
* Capacitors. Capacitors are passive components that store electricity as an electrostatic field and release electric current. Capacitors are often used along with transistors in dynamic RAM (DRAM) to help maintain stored data.
* Diodes. Diodes are specialized components with two nodes that conduct electric current in one direction only. A diode can permit or block the flow of electric current and can be used for various roles, such as switches, rectifiers, voltage regulators or signal modulators.

What are the types of microchips?

Microchips drive all of today's electronics. Not only do these include computers, but also smartphones, network switches, home appliances, car and aircraft components, televisions and amplifiers, internet of things devices and countless other electronic systems. Microchips generally fall into one of the following two categories:

* Logic. This type of microchip does all the heavy lifting, processing the instructions and data that are fed to the device and subsequently to the chip in that device. The most common and widely used type of logic microchip is the central processing unit (CPU). However, this category also includes more specialized chips, such as graphical processing units (GPUs) and neural net processors.

* Memory. This type of microchip stores data. Data storage is either volatile or non-volatile. volatile memory chips require a constant source of power to retain their data. DRAM is a common example of a volatile memory chip. A non-volatile chip is one that can persist data even if the power supply is disrupted. A good example of non-volatile memory is NAND flash. Volatile memory devices tend to perform much better than non-volatile devices, although a number of efforts are underway to bridge the gap between the two, such as storage class memory.

Although many microchips focus on logic or memory only, other types of chips incorporate both, along with other capabilities. For example, system-on-a-chip (SoC) ICs are now widely used in devices such as smartphones and wearable technology and have begun making headway into the computer market, as evidenced by the Apple silicon series of chips. Another example is the application-specific IC, which can also include logic, memory and other capabilities, much like the SoC chip, except that the ASIC chip is customized for a specific purpose, such as medical equipment or an automotive component.

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#6 Re: Dark Discussions at Cafe Infinity » crème de la crème » Today 00:03:41

2461) Richard Laurence Millington Synge

Gist:

Work

When a drop of a liquid containing a mixture of various substances is placed on paper, the liquid begins to spread out on the paper. The various substances in the mixture spread at different speeds, however, which gives rise to marks on the paper with different colors. In the 1940s Richard Synge and Archer Martin used this and similar phenomena in gas mixtures, for example, to develop different types of chromatography—methods for separating substances in mixtures and for determining the composition of mixtures.

Summary

R.L.M. Synge (born Oct. 28, 1914, Liverpool, Eng.—died Aug. 18, 1994, Norwich, Norfolk) was a British biochemist who in 1952 shared the Nobel Prize for Chemistry with A.J.P. Martin for their development of partition chromatography, notably paper chromatography.

Synge studied at Winchester College, Cambridge, and received his Ph.D. at Trinity College there in 1941. He spent his entire professional career conducting research, initially with Martin under the auspices of the Wool Industries Research Association, Leeds (1941–43). The two men developed partition chromatography, a technique that is used to separate mixtures of closely related chemicals such as amino acids for identification and further study. Synge used paper chromatography to work out the exact structure of the simple protein molecule gramicidin S, which helped to pave the way for the English biochemist Frederick Sanger’s elucidation of the structure of the insulin molecule.

Synge did research at the Lister Institute of Preventive Medicine, London (1943–48), and at the Rowett Research Institute, near Aberdeen, Scot. (1948–67). He became a biochemist at the Food Research Institute, Norwich (1967–76), and was also an honorary professor of biological sciences at the University of East Anglia (1968–84).

Details

Richard Laurence Millington Synge (28 October 1914 – 18 August 1994) was a British biochemist, and shared the 1952 Nobel Prize in Chemistry for the invention of partition chromatography with Archer Martin.

Life

Richard Laurence Millington Synge was born in West Kirby on 28 October 1914, the son of Lawrence Millington Synge, a Liverpool stock-broker, and his wife, Katherine C. Swan.

Synge was educated at the Old Hall in Wellington, Shropshire and at Winchester College. He then studied Chemistry at Trinity College, Cambridge.

He spent his entire career in research, at the Wool Industries Research Association, Leeds (1941–1943), Lister Institute for Preventive Medicine, London (1943–1948), Rowett Research Institute, Aberdeen (1948–1967), and Food Research Institute, Norwich (1967–1976).

It was during his time in Leeds that he worked with Archer Martin, developing partition chromatography, a technique used in the separation mixtures of similar chemicals, that revolutionised analytical chemistry. Between 1942 and 1948 he studied peptides of the protein group gramicidin, work later used by Frederick Sanger in determining the structure of insulin. In March 1950 he was elected a Fellow of the Royal Society for which his candidature citation read:

Distinguished as a biochemist. Was the first to show the possibility of using counter-current liquid-liquid extraction in the separation of N-acetylamino acids. In collaboration with A.J.P. Martin this led to the development of partition chromatography, which they have applied with conspicuous success in problems related to the composition and structure of proteins, particularly wool keratin. Synge's recent work on the composition and structure of gramicidins is outstanding and illustrates vividly the great advances in technique for which he and Martin are responsible.

— "Library and Archive catalogue". Royal Society. Archived from the original on 27 July 2011. Retrieved 24 October 2010.

In 1963 he was elected a Fellow of the Royal Society of Edinburgh. His proposers were Magnus Pyke, Andrew Phillipson, Sir David Cuthbertson and John Andrew Crichton.

He was for several years the treasurer of the Chemical Information Group of the Royal Society of Chemistry, and was an honorary Professor in Biological Sciences at the University of East Anglia from 1968 to 1984. He was awarded an honorary Doctor of Science (ScD) from the University of East Anglia in 1977, and an honorary doctorate from the Faculty of Mathematics and Science at Uppsala University, Sweden in 1980.

Personal life

In 1943 Synge married Ann Davies Stephen (1916–1997). Ann Stephen was the daughter of psychologist Karin Stephen and psychoanalyst Adrian Stephen. Ann's sister Judith (1918–1972) was married to documentary artist and photographer Nigel Henderson.

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#7 Jokes » Nut Jokes - VI » Today 00:03:24

Jai Ganesh
Replies: 0

Q: What did the boy squirrel say to the girl squirrel?
A: Want these nuts?
* * *
Q: What do you call an animal that solves crimes?
A: Squirrel-lock Holmes.
* * *
Q: What do squirrels drink?
A: Nut-Tea.
* * *
Psychologist: What brings you here today?
Squirrel: I realized I am what I eat.....Nuts.
* * *

#8 Dark Discussions at Cafe Infinity » Comfort Quotes - II » Today 00:02:57

Jai Ganesh
Replies: 0

Comfort Quotes - II

1. There is nothing like staying at home for real comfort. - Jane Austen

2. The lust for comfort, that stealthy thing that enters the house a guest, and then becomes a host, and then a master. - Khalil Gibran

3. Prosperity is not without many fears and distastes; adversity not without many comforts and hopes. - Francis Bacon

4. Life is made up, not of great sacrifices or duties, but of little things, in which smiles and kindness, and small obligations given habitually, are what preserve the heart and secure comfort. - Humphry Davy

5. In poverty and other misfortunes of life, true friends are a sure refuge. The young they keep out of mischief; to the old they are a comfort and aid in their weakness, and those in the prime of life they incite to noble deeds. - Aristotle

6. A scholar who cherishes the love of comfort is not fit to be deemed a scholar. - Lao Tzu

7. Physical comforts cannot subdue mental suffering, and if we look closely, we can see that those who have many possessions are not necessarily happy. In fact, being wealthy often brings even more anxiety. - Dalai Lama

8. If a nation values anything more than freedom, it will lose its freedom, and the irony of it is that if it is comfort or money that it values more, it will lose that too. - W. Somerset Maugham.

#9 Re: Jai Ganesh's Puzzles » General Quiz » Yesterday 18:54:54

Hi,

#10795. What does the term in Geography Desertification mean?

#10796. What does the term in Geography Desire path mean?

#10 Re: Jai Ganesh's Puzzles » English language puzzles » Yesterday 18:39:37

Hi,

#6001. What does the adjective horrendous mean?

#6002. What does the noun hornet mean?

#11 Re: Jai Ganesh's Puzzles » Doc, Doc! » Yesterday 18:20:09

Hi,

#2597. What does the medical term Hyperplasia mean?

#14 This is Cool » Nitrogen Dioxide » Yesterday 17:11:47

Jai Ganesh
Replies: 0

Nitrogen Dioxide

Gist

Nitrogen dioxide is a highly reactive, reddish-brown toxic gas with a pungent odor, acting as a major air pollutant and strong oxidant. Primarily produced by burning fossil fuels in vehicles, power plants, and industrial equipment, it poses severe respiratory health risks, including asthma, and contributes to smog, acid rain, and ozone formation.

NO2 is comprised of one atom of nitrogen and two atoms of oxygen, and is a gas at ambient temperatures. It has a pungent smell, and is brownish red in color.

Summary

Nitrogen dioxide is a chemical compound with the formula NO2. One of several nitrogen oxides, nitrogen dioxide is a reddish-brown gas. It is a paramagnetic, bent molecule with C2v point group symmetry. Industrially, NO2 is an intermediate in the synthesis of nitric acid, millions of tons of which are produced each year, primarily for the production of fertilizers.

Nitrogen dioxide is poisonous and can be fatal if inhaled in large quantities. Cooking with a gas stove produces nitrogen dioxide which causes poorer indoor air quality. Combustion of gas can lead to increased concentrations of nitrogen dioxide throughout the home environment which is linked to respiratory issues and diseases. The LC50 (median lethal dose) for humans has been estimated to be 174 ppm for a 1-hour exposure. It is also included in the NOx family of atmospheric pollutants.

Properties

Nitrogen dioxide is a reddish-brown gas with a pungent, acrid odor above 21.2 °C (70.2 °F; 294.3 K) and becomes a yellowish-brown liquid below 21.2 °C (70.2 °F; 294.3 K). It forms an equilibrium with its dimer, dinitrogen tetroxide (N2O4), and converts almost entirely to N2O4 below −11.2 °C (11.8 °F; 261.9 K).

The bond length between the nitrogen atom and the oxygen atom is 119.7 pm. This bond length is consistent with a bond order between one and two. Nitrogen dioxide is a doublet state.

Details

Nitrogen dioxide, or NO2, is a gaseous air pollutant composed of nitrogen and oxygen and is one of a group of related gases called nitrogen oxides, or NOx. Nitrogen dioxide forms when fossil fuels such as coal, oil, methane gas (natural gas) or diesel are burned at high temperatures. NO2 and other nitrogen oxides in the outdoor air contribute to particle pollution and to the chemical reactions that make ozone. It is one of six widespread air pollutants for which there are national air quality standards to limit their levels in the outdoor air. NO2 can also form indoors when fuels like wood or gas are burned.

What Are the Health Effects of Nitrogen Dioxide Pollution?

Nitrogen dioxide causes a range of harmful effects on the lungs, including:

* Increased inflammation of the airways;
* Worsened cough and wheezing;
* Reduced lung function;
* Increased asthma attacks; and
* Greater likelihood of emergency department and hospital admissions.

Scientific evidence suggests that exposure to NO2 could likely cause asthma in children.

A 2022 review of multiple studies found that elevated levels of NO2, as well as elevated particulate matter and sulfur dioxide, were strongly associated with heart and lung harm, affected pregnancy and birth outcomes, and were likely associated with increased risk of kidney and neurological harm, autoimmune disorders and cancer.

What Are the Sources of Nitrogen Dioxide Emissions?

As of 2020, human-made sources in the U.S. emit 7.64 million short tons of nitrogen oxides per year (down from 15 million short tons per year in 2011) mainly from burning fuels. Trucks, buses, and cars are the largest sources of NO2 emissions, followed by diesel-powered non-road equipment, industrial processes such as oil and gas production, industrial boilers and other movable engines, and coal-fired power plants. Emissions of nitrogen dioxide will decline as cleanup of many of these sources continue in future years.

Where Do High NO2 Concentrations Occur?

Monitors show the highest concentrations of outdoor NO2 in large urban regions such as the Northeast corridor, Chicago and Los Angeles. Levels are higher on or near heavily traveled roadways.

It is important to note that NO2 and other nitrogen oxides are also produced from burning natural gas (methane), both outdoors and indoors. Outdoors, this can include gas-fired power plants and from facilities that extract, process or transport oil and gas if they burn it in flares or to power equipment. Indoors, appliances such as stoves, dryers and space heaters that burn natural gas, liquified petroleum gas (or LPG, which includes propane and butane) and kerosene can produce substantial amounts of nitrogen dioxide. If those appliances are not fully vented to the outside, levels of NO2 can build up to unhealthy levels indoors.

Who Is at Risk?

While everyone is at risk from health impacts of nitrogen dioxide pollution, those that live near the emission sources are at higher risk. Other vulnerable subpopulations at higher risk from nitrogen dioxide exposure include:

* Individuals who are pregnant;
* Infants, children and teens;
* Older adults (>65 years of age);
* People with pre-existing medical conditions such as asthma, chronic obstructive pulmonary disease (COPD), cardiovascular disease, diabetes, lung cancer
* Current or former smokers;
* People with low socioeconomic status; and
* People of color.

What Can We Do about It?

The good news is that for much of the nation, the outdoor air has much lower levels of nitrogen dioxide now than in previous decades. Under the federal Clean Air Act, more protective standards nationwide have helped drive down nitrogen dioxide emissions. Power plants, industrial sites and on-road vehicles are cleaner than they used to be, which has driven nationwide improvement in air quality. However, far too many people still breathe in unhealthy levels of nitrogen dioxide pollution.

Individuals can take steps to protect themselves on days with unhealthy levels of air pollutants and also ask policymakers at all levels of government to continue to require cleanup of air pollution.

Additional Information:

What is Nitrogen dioxide?

NO2 is a highly poisonous gas with the chemical name Nitrogen dioxide.

It is also called Nitrogen (IV) oxide or Deutoxide of nitrogen. It is one of the major atmospheric pollutants that absorb UV light and stops to reach the earth’s surface.

Nitrogen (IV) oxide is a yellowish-brown liquid in its compressed form or reddish-brown gas. Its vapours are heavier when compared to air.

Nitrogen dioxide Sources – NO2
Over 98 percent of man-made N0, emissions result from Combustion with the majority due to stationary sources. Combustion generated oxides of nitrogen are emitted predominantly as nitric oxide, N0, a relatively harmless gas, but one which is rapidly converted in the atmosphere to the toxic nitrogen dioxide.

Nitrogen dioxide is also a precursor in the formation of nitrate serosols and nitrosamines, the health effects of which are under study. Because of the quantity generated and their potential for widespread adverse effects on public health and welfare, nitrogen oxides are among the atmospheric pollutants for which standards and regularly controls have been established both by the U.S. c

NO2 Uses (Nitrogen dioxide)

* Nitrogen dioxide is used as an intermediate in the production of nitric acid.
* Used in the manufacturing of oxidized cellulose compounds.
* Used as a catalyst.
* Used as an intermediate in the production of sulphuric acid.
* Used as an oxidizer for rocket fuels.
* Used as a nitrating agent.
* Used to bleach flour.
* Used as an oxidizing agent.

Health Hazards
Severe exposures of Deutoxide of nitrogen can be fatal. When in contact it causes a burning sensation in the eyes and skin. When in liquid form it causes frostbite. It is reported to react with the blood to form methemoglobin. When heated to decompose, it releases toxic fumes of nitrogen oxides.

Nitrogen dioxide is an irritant gas which causes inflammation of the airways at high concentrations. NO2 mainly affects respiratory conditions which cause high levels of airway inflammation. Long-term exposure will decrease lung capacity, increase the probability of respiratory problems and increase allergy response. NO2 also contributes to the production of small particles (PM) and ozone at ground level, both associated with harmful effects on the environment.

Frequently Asked Questions – FAQs

Q1: What is nitrogen dioxide used for?
A1: Nitrogen Dioxide, NO2; was used as a catalyst in some oxidation reactions; as an inhibitor to prevent the polymerization of acrylates during distillation; as an organic compound nitrating agent; as an oxidizing agent; as a rocket fuel; as a flour bleaching agent.

Q2: What does nitrogen dioxide do?
A2: The key consequence of breathing in elevated nitrogen dioxide levels is an increased risk of respiratory disorders. Nitrogen dioxide inflames the lungs ‘ lining and can decrease immunity to infections of the lungs. This can lead to wheezing, coughing, colds, pneumonia, and bronchitis issues.

Q3: Does nitrogen dioxide cause global warming?
A3: Nitric oxide and nitrogen dioxide are the two most toxic and dangerous nitrogen oxides. Nitrous oxide, often referred to as laughing gas, is a greenhouse gas which contributes to global warming.

Q4: What are the main sources of nitrogen oxides?
A4: Natural causes include volcanoes, rivers, biological collapse and bolts of lightning. Every year human activities add 24 million tons of nitrogen oxides to our atmosphere.

Q5: Is nitrogen dioxide heavier than air?
A5: At high concentrations, nitric oxide is quickly oxidized into the air to produce nitrogen dioxide. Expositions. Nitrogen dioxide is heavier than air, so exposure can result in asphyxiation in poorly ventilated, sealed, or low-lying areas. The gasses at room temperature are both nitrogen dioxide and nitric oxide.

Q6: What is nitrogen dioxide made from?
A6: Nitrogen dioxide is an irritant gas which causes inflammation of the airways at high concentrations. As nitrogen is released during the combustion of fuel it reacts with atoms of oxygen to produce nitric oxide (NO). It additionally reacts with oxygen to form nitrogen dioxide (NO2).

Q7: What causes high nitrogen dioxide levels?
A7: Nitrogen dioxide comes from cars, power stations, and commercial and off-road outlets such as building machinery, lawn machines, and gardening. Such outlets both use fossil fuels. People living or working close to busy highways can suffer high exposure.

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#15 Science HQ » Diabetic Retinopathy » Yesterday 16:38:19

Jai Ganesh
Replies: 0

Diabetic Retinopathy

Gist

Diabetic retinopathy is a serious diabetes complication caused by high blood sugar damaging retinal blood vessels, potentially leading to blindness. It often shows no early symptoms but progresses from mild vision changes to severe, permanent vision loss. Treatment includes managing blood sugar, laser therapy, or injections to stop vessel leakage and growth.

Summary

Diabetic retinopathy (also known as diabetic eye disease) is a medical condition in which damage occurs to the retina due to diabetes. It is a leading cause of blindness in developed countries and one of the leading causes of sight loss in the world, even though there are many new therapies and improved treatments for helping people living with diabetes.

Diabetic retinopathy affects up to 80 percent of those who have had both type 1 and type 2 diabetes for 20 years or more. In at least 90% of new cases, progression to more aggressive forms of sight-threatening retinopathy and maculopathy could be reduced with proper treatment and monitoring of the eyes. The longer a person has diabetes, the higher their chances of developing diabetic retinopathy. Each year in the United States, diabetic retinopathy accounts for 12% of all new cases of blindness. It is also the leading cause of blindness in people aged 20 to 64.

Signs and symptoms

Nearly all people with diabetes develop some degree of retina damage ("retinopathy") over several decades with the disease. For many, that damage can only be detected by a retinal exam, and has no noticeable effect on vision. Over time, progressive retinal damage may appear on a retinal exam, first with small bulges in retinal blood vessels called microaneurysms. Then larger abnormalities in retinal vessels: cotton wool spots, hemorrhages, lipid deposits called "hard exudates", intraretinal microvascular abnormalities, and abnormal-looking retinal veins. Eventually, many progress to a stage where new blood vessels grow throughout the retina. These new blood vessels often break and bleed. Minor bleeding can cause dark floating spots obstructing vision; major bleeding can completely block vision.

Around half of people with diabetic retinopathy develop swelling of the macula, called macular edema, which can begin at any time. If the swelling occurs near the center of the macula, it can cause vision disruptions ranging from mildly blurred vision to severe loss of the center of an affected person's visual field. Left untreated, around 30% of those with such swelling experience vision disruption over the next 3–5 years. Macular edema is the most common cause of vision loss in people with diabetic retinopathy.

The repeated processes of blood vessel growth, swelling, and scarring can eventually cause retinal detachment, which manifests as the sudden appearance of dark floating spots, flashes of light, or blurred vision.

Details:

What is diabetic retinopathy?

Diabetic retinopathy is a condition that occurs when diabetes affects the blood vessels and nerve tissue in the retina.

There are two stages of diabetic retinopathy:


Nonproliferative retinopathy is the early stage of the disease in which blood vessels swell and leak.  In some cases, this can cause macular edema (swelling of the retina) which may result in mild vision loss but can be treated.  There can also be early changes to the nerve cells in the retina that may affect vision, in part due loss of adequate blood supply.

Proliferative retinopathy is the advanced stage where abnormal new blood vessels grow on the surface of the retina. These vessels may break and bleed into the vitreous, the clear watery gel that fills the eye, and cause severe vision loss. This stage of diabetic retinopathy typically requires urgent treatment.

While diabetic retinopathy often cannot be completely prevented, you can reduce your risk of having it develop or progress. Controlling your blood sugar slows the start of retinopathy and prevents it from getting worse. It also lessens the need for laser surgery or other procedures that treat severe retinopathy.

What causes diabetic retinopathy?

Diabetic retinopathy is caused by changes in the blood vessels of the retina, the light-sensitive layer of tissue at the back of the inner eye. In some people with diabetic retinopathy, the blood vessels in the retina may swell and leak fluid. In others, abnormal new blood vessels grow on the surface of the retina. These changes may result in severe vision loss.

Who is at risk for diabetic retinopathy?

Anyone with diabetes is at risk for diabetic retinopathy. The longer you have diabetes, the more likely you are to develop diabetic retinopathy. Your risk rises if you have diabetes and you also smoke, have high blood pressure, or are pregnant.

What are the symptoms of diabetic retinopathy?

In the early stages of diabetic retinopathy, you may have no symptoms and your vision may not change until the disease gets worse. When the disease progresses, you may have blurry or double vision, dark or floating spots, pain or pressure in one or both eyes, rings, flashing lights, or blank spots in your vision.

A condition called macular edema may occur from diabetic retinopathy. Macular edema occurs when the macula, the central part of the retina, swells from the leaking fluid and causes blurred vision. When new vessels grow on the surface of the retina, they can bleed into the eye and lead to a decrease in vision as well.

How is diabetic retinopathy diagnosed?

Your eye doctor may do the following tests, as well as a complete health history and eye exam, to diagnose diabetic retinopathy:

* Visual acuity test. The common eye chart test that measures central vision ability at various distances.
* Tonometry. A standard test that checks the pressure (intraocular pressure, or IOP) inside the eye.
* Pupil dilation. An examination where your pupil is widened with eye drops for a close-up of the eye’s lens and retina.
* Ophthalmoscopy. An examination where your doctor looks very closely at the retina using a special magnifying glass.
* Fluorescein angiography. A test where an organic dye is injected into the bloodstream to show the blood vessels in the eye. This occurs while pictures are taken with a special camera and will show your doctor if the blood vessels are leaking or no longer supplying areas of retina.
* Optical coherence tomography. A test where light waves are used to make detailed images of the retina.

How is diabetic retinopathy treated?

Treatment for diabetic retinopathy will depend on your symptoms, age and general health. It will also depend on how severe the condition is.

People with advanced retinopathy have a good chance of keeping their vision if they are treated before the retina becomes severely damaged. Treatment for diabetic retinopathy may include one or a combination of the following:

* Laser surgery. This is often used to treat proliferative retinopathy and sometimes macular edema. It involves shrinking the abnormal blood vessels, or sealing the leaking ones.
* Vitrectomy. Vitrectomy is a procedure that involves removing the jelly-like substance (vitreous) that fills the center of the eye. The vitreous is replaced with a balanced saline solution.
* Injections. Certain medications can be injected into the eye to slow the growth of the abnormal vessels of the retina and to treat macular edema.

Can diabetic retinopathy be prevented?

Although it can be challenging to prevent diabetic retinopathy, there are steps you can take to reduce the risk of it developing or progressing.

Get a diabetic eye exam once a year

An eye exam can help diagnose eye problems for treatment and can alert you and your health care provider if your diabetes needs to be better controlled. Women with diabetes should have an eye exam before pregnancy or in the first trimester. Continue to be monitored every trimester and for one year after birth depending on the severity of the retinopathy.

Follow your diabetes management plan

The following steps should be taken to maximize your treatment:

* Take medicines as directed.
* Use insulin as directed, if needed.
* Eat a healthy and balanced diet to manage blood sugar level.
* Exercise to lower and help the body use blood sugar.
* Test blood-sugar levels regularly.
* Test hemoglobin A1c levels regularly.
* Test urine for ketone levels regularly.
* Have regular health care follow-ups to evaluate diabetes control and rule out or treat other risk factors, such as high blood pressure.

Better control of blood sugar slows the onset and progression of retinopathy and lessens the need for laser surgery or other procedures for treating severe retinopathy.

Additional Information:

The Two Stages of Diabetic Eye Disease

There are two main stages of diabetic eye disease.

NPDR (non-proliferative diabetic retinopathy)

This is the early stage of diabetic eye disease and is caused by leaky blood vessels. Many people with diabetes have it.

With NPDR, tiny blood vessels leak, making the retina swell. When the macula swells, it is called macular edema. This is the most common reason why people with diabetes lose their vision. Sometimes tiny particles called exudates can form in the retina. These can affect your vision too.

When blood vessels close off, this is called macular ischemia. When that happens, blood cannot reach the macula.

If you have NPDR, your vision will be blurry.

PDR (proliferative diabetic retinopathy)

PDR is the more advanced stage of diabetic eye disease. It happens when the retina starts growing new blood vessels. This is called neovascularization. These fragile new vessels often bleed into the vitreous. If they only bleed a little, you might see a few dark floaters. If they bleed a lot, it might block all vision.

These new blood vessels can form scar tissue. Scar tissue can cause problems with the macula or lead to a detached retina.

PDR is very serious, and can steal both your central and peripheral (side) vision.

What Happens When You Have Diabetic Retinopathy?

You can have diabetic retinopathy and not know it. This is because it often has no symptoms in its early stages. As diabetic retinopathy gets worse, you will notice symptoms such as:

* more floaters
* blurry vision
* vision that changes sometimes from blurry to clear
* blank or dark areas in your field of vision
* poor night vision
* colors appearing faded or washed out
* loss of vision

Diabetic retinopathy symptoms can affect both eyes.

Diabetic Retinopathy Diagnosis

Drops will be put in your eye to dilate (widen) your pupil. This allows your ophthalmologist to look through a special lens to see the inside of your eye.

Your doctor may do optical coherence tomography (OCT) to look closely at the retina. A machine scans the retina and provides detailed images of its thickness. This helps your doctor find and measure swelling of your macula.

Fluorescein angiography or OCT angiography helps your doctor see what is happening with the blood vessels in your retina. Fluorescein angiography uses a yellow dye called fluorescein, which is injected into a vein (usually in your arm). The dye travels through your blood vessels. A special camera takes photos of the retina as the dye travels throughout its blood vessels. It shows if any blood vessels are blocked or leaking fluid. It also shows if any abnormal blood vessels are growing. OCT angiography is a newer technique and does not need dye to look at the blood vessels. But it does not provide as much information as fluorescein angiography.

Can Diabetic Retinopathy Go Away?

Your treatment is based on what your ophthalmologist sees in your eyes. Treatment options may include:

* Medical control

Controlling your blood sugar and blood pressure can stop vision loss. Carefully follow the diet your nutritionist has recommended. Take the medicine your diabetes doctor prescribed for you. Sometimes, good sugar control can even bring some of your vision back. Controlling your blood pressure keeps your eye’s blood vessels healthy.

* Medicine

One class of medication is called anti-VEGF. These include Avastin, Eylea, and Lucentis. They help reduce swelling of the macula, slowing vision loss and perhaps improving vision. These drugs are given by injections (shots) in the eye. Steroid medicine is another option to reduce macular swelling. This is also given as injections in the eye. Your doctor will recommend how many medication injections you will need based on your response to treatment.

* Laser surgery

Laser surgery might be used to seal off leaking blood vessels. This can reduce swelling in the retina. Laser surgery can also help shrink blood vessels and prevent them from growing again. Often, more than one treatment is needed.

* Vitrectomy

If you have advanced PDR, your ophthalmologist may recommend surgery called vitrectomy. Your ophthalmologist removes vitreous gel and blood in the back of your eye. This allows light rays to focus properly on the retina again. Scar tissue also might be removed from the retina and laser may be used at the time of surgery.

5 Ways to Prevent Vision Loss from Diabetic Retinopathy

* If you have diabetes, talk with your primary care doctor about controlling your blood sugar. High blood sugar damages retinal blood vessels. That causes vision loss.
* Do you have high blood pressure or kidney problems? Ask your doctor about ways to manage and treat these problems.
* See your ophthalmologist regularly for dilated eye exams. Diabetic retinopathy may be found before you even notice any vision problems.
* If you notice vision changes in one or both eyes, call your ophthalmologist right away.
* Get treatment for diabetic retinopathy as soon as possible. This is the best way to prevent vision loss.

Do You Have Diabetes and Need an Eyeglasses Exam?

Changes in blood sugar levels can affect your vision. Make sure your blood sugar is under control for at least a week before an eye exam. Eyeglasses prescribed when your blood sugar levels are stable work best!

Diabetic-Retinopathy-Stages.png

#17 Re: This is Cool » Miscellany » Yesterday 00:04:16

2523) Hematite

Gist

Hematite is a common iron oxide mineral and the world's most important iron ore, containing roughly 70% iron. It is recognized by its brilliant metallic gray to dull red color and characteristic reddish-brown streak, which is used for pigments and polishing. It is abundant on Earth and causes the red coloration on Mars.

Hematite occurs in a variety of igneous and metamorphic rocks, but is most abundant in sedimentary settings. In sedimentary rocks, hematite can either have formed from have originally formed directly from direct precipitation out of marine waters, or as a concentration and enrichment deposit formed from groundwater.

Summary

Hematite is a heavy and relatively hard oxide mineral, ferric oxide (Fe2O3), that constitutes the most important iron ore because of its high iron content (70 percent) and its abundance. Its name is derived from the Greek word for “blood,” in allusion to its red colour. Many of the various forms of hematite have separate names. The steel-gray crystals and coarse-grained varieties have a brilliant metallic lustre and are known as specular iron ore; thin scaly types are called micaceous hematite. Much hematite occurs in a soft, fine-grained, earthy form called red ochre or ruddle. Intermediate between these types are compact varieties, often with a reniform surface (kidney ore) or a fibrous structure (pencil ore). Red ochre is used as a paint pigment; a purified form, rouge, is used to polish plate glass.

The most important deposits of hematite are sedimentary in origin. The world’s largest production (nearly 75 million tons of hematite annually) comes from a sedimentary deposit in the Lake Superior district in North America. Other important deposits include those at Minas Gerais, Brazil (where the hematite occurs in metamorphosed sediments); Cerro Bolívar, Venezuela; and Labrador and Quebec, Canada. Hematite is found as an accessory mineral in many igneous rocks; commonly as a weathering product of siderite, magnetite, and other iron minerals; and almost universally as a pigmenting agent of sedimentary and other rocks. For detailed physical properties, see oxide mineral.

Details

Hematite is one of the most abundant minerals on Earth's surface and in the shallow crust. It is an iron oxide with a chemical composition of Fe2O3. It is a common rock-forming mineral found in sedimentary, metamorphic, and igneous rocks at locations throughout the world.

Hematite is the most important ore of iron. Although it was once mined at thousands of locations around the world, today almost all of the production comes from a few dozen large deposits where significant equipment investments allow companies to efficiently mine and process the ore. Most ore is now produced in China, Australia, Brazil, India, Russia, Ukraine, South Africa, Canada, Venezuela, and the United States.

Hematite has a wide variety of other uses, but their economic significance is very small compared to the importance of iron ore. The mineral is used to produce pigments, preparations for heavy media separation, radiation shielding, ballast, and many other products.

Physical Properties of Hematite

Hematite has an extremely variable appearance. Its luster can range from earthy to submetallic to metallic. Its color ranges include red to brown and black to gray to silver. It occurs in many forms that include micaceous, massive, crystalline, botryoidal, fibrous, oolitic, and others.

Even though hematite has a highly variable appearance, it always produces a reddish streak. Students in introductory geology courses are usually surprised to see a silver-colored mineral produce a reddish streak. They quickly learn that the reddish streak is the most important clue for identifying hematite.

Hematite is not magnetic and should not respond to a common magnet. However, many specimens of hematite contain enough magnetite that they are attracted to a common magnet. This can lead to an incorrect assumption that the specimen is magnetite or the weakly magnetic pyrrhotite. The investigator must check other properties to make a proper identification.

If the investigator checks the streak, a reddish streak will rule out identification as magnetite or pyrrhotite. Instead, if the specimen is magnetic and has a reddish streak, it is most likely a combination of hematite and magnetite.

Composition of Hematite

Pure hematite has a composition of about 70% iron and 30% oxygen by weight. Like most natural materials, it is rarely found with that pure composition. This is particularly true of the sedimentary deposits where hematite forms by inorganic or biological precipitation in a body of water.

Minor clastic sedimentation can add clay minerals to the iron oxide. Episodic sedimentation can cause the deposit to have alternating bands of iron oxide and shale. Silica in the form of jasper, chert, or chalcedony can be added by chemical, clastic, or biological processes in small amounts or in significant episodes. These layered deposits of hematite and shale or hematite and silica have become known as the "banded iron formations".

Geologic Occurrence

Hematite is found as a primary mineral and as an alteration product in igneous, metamorphic, and sedimentary rocks. It can crystallize during the differentiation of a magma or precipitate from hydrothermal fluids moving through a rock mass. It can also form during contact metamorphism when hot magmas react with adjacent rocks.

The most important hematite deposits formed in sedimentary environments. About 2.4 billion years ago, Earth’s oceans were rich in dissolved iron, but very little free oxygen was present in the water. Then a group of cyanobacteria became capable of photosynthesis. The bacteria used sunlight as an energy source to convert carbon dioxide and water into carbohydrates, oxygen, and water. This reaction released the first free oxygen into the ocean environment. The new oxygen immediately combined with the iron to form hematite, which sank to the bottom of the seafloor and became the rock units that we know today as the banded iron formations.

Soon, photosynthesis was occurring in many parts of Earth’s oceans, and extensive hematite deposits were accumulating on the seafloor. This deposition continued for hundreds of millions of years - from about 2.4 to 1.8 million years ago. This allowed the formation of iron deposits hundreds to several thousand feet thick that are laterally persistent over hundreds to thousands of square miles. They comprise some of the largest rock formations in Earth’s rock record.

Many of the sedimentary iron deposits contain both hematite and magnetite as well as other iron minerals. These are often in intimate association, and the ore is mined, crushed, and processed to recover both minerals. Historically, much of the hematite was not recovered and was sent to tailings piles. More efficient processing today allows more hematite to be recovered from the ore. The tailings can also be reprocessed to recover additional iron and reduce tailings volume.

Hematite on Mars?

NASA has discovered that hematite is one of the most abundant minerals in the rocks and soils on the surface of Mars. An abundance of hematite in Martian rocks and surface materials gives the landscape a reddish brown color and is why the planet appears red in the night sky. It is the origin of Mars' "Red Planet" nickname.

Uses of Hematite (Iron Ore)

Hematite is the world’s most important ore of iron. Although magnetite contains a higher percentage of iron and is easier to process, hematite is the leading ore because it is more abundant and present in deposits in many parts of the world.

Hematite is mined in some of the largest mines in the world. These mines require investments of billions of dollars, and some will remove over 100 million tons of ore per year. These open-pit mines can be hundreds to thousands of feet deep and several miles across by the time they have been worked to completion.

China, Australia, Brazil, India, Russia, Ukraine, South Africa, and the United States are the world’s leading producers of iron ore (includes hematite, magnetite, and other ores). Iron ore production in the United States occurs in Michigan and Minnesota.

Uses of Hematite (Pigment)

The name hematite is from the Greek word "haimatitis" which means "blood-red." That name stems from the color of hematite when it has been crushed to a fine powder. Primitive people discovered that hematite could be crushed and mixed with a liquid for use as a paint or cosmetic. Cave paintings, known as "pictographs," dating back to 40,000 years ago were created with hematite pigments.

Hematite continues to be one of the most important pigment minerals. It has been mined at many locations around the world and has been traded extensively as a red pigment. During the Renaissance when many painters began using oils and canvas, hematite was one of the most important pigments. Hematite color was opaque and permanent. It could be mixed with a white pigment to produce a variety of pink colors that were used to paint flesh.

Uses of Hematite (Gem Material)

Hematite is a minor gem material used to produce cabochons, beads, small sculptures, tumbled stones, and other items. The material used to manufacture these products is a silver-colored hematite with a solid, uniform texture. The bright silver color of hematite and its "weighty feel" make it a very popular tumbled stone.

Uses of Hematite (Healing Stone)

Some people believe that carrying pieces of tumble-polished hematite, known as "healing stones," will bring relief from certain medical problems. There is no scientific proof that this use of hematite has any positive effect beyond being a placebo. Using hematite as a "healing stone" or a "healing crystal" can actually be harmful because it diverts people from seeing a doctor who can provide proper care. Then when the person with the problem finally decides to see a doctor, their situation is more severe.

Other Uses of Hematite

Hematite is used for a number of other purposes. It is a very dense and inexpensive material that is effective at stopping x-rays. For that reason it is used for radiation shielding around medical and scientific equipment. The low cost and high density of hematite and other iron ores also makes them useful as ballast for ships.

Hematite can also be ground to a fine powder that when mixed with water will make a liquid with a very high specific gravity. These liquids are used in the "float-sink" processing of coal and other mineral material. The crushed coal, which has a very low specific gravity, is placed on the heavy liquid and the light clean coal floats, while high-specific-gravity impurities such as pyrite sink.

Finally, hematite is the material used to make polishing compounds known as "red rouge" and "jeweler's rouge." Red rouge is a hematite powder used to polish brass and other soft metals. It can be added to crushed corn cob media or crushed walnut shell media for tumble-polishing brass shell casings. Jeweler's rouge is a paste used on a soft cloth to polish gold and silver jewelry.

Additional Information

Hematite, also spelled as haematite, is a common iron oxide compound with the formula Fe2O3 and is widely found in rocks and soils. Hematite crystals belong to the rhombohedral lattice system which is designated the alpha polymorph of Fe2O3. It has the same crystal structure as corundum (Al2O3) and ilmenite (FeTiO3). With this crystal structure geometry it forms a complete solid solution at temperatures above 950 °C (1,740 °F).

Hematite occurs naturally in black to steel or silver-gray, brown to reddish-brown, or red colors. It is mined as an important ore mineral of iron. It is electrically conductive. Hematite varieties include kidney ore, martite (pseudomorphs after magnetite), iron rose and specularite (specular hematite). While these forms vary, they all have a rust-red streak. Hematite is not only harder than pure iron, but also much more brittle. The term kidney ore may be broadly used to describe botryoidal, mammillary, or reniform hematite.[8] Maghemite is a polymorph of hematite (γ-Fe2O3) with the same chemical formula, but with a spinel structure like magnetite.

Large deposits of hematite are found in banded iron formations. Gray hematite is typically found in places that have still, standing water, or mineral hot springs, such as those in Yellowstone National Park in North America. The mineral may precipitate in the water and collect in layers at the bottom of the lake, spring, or other standing water. Hematite can also occur in the absence of water, usually as the result of volcanic activity.

Clay-sized hematite crystals also may occur as a secondary mineral formed by weathering processes in soil, and along with other iron oxides or oxyhydroxides such as goethite, which is responsible for the red color of many tropical, ancient, or otherwise highly weathered soils.

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#18 Re: Dark Discussions at Cafe Infinity » crème de la crème » Yesterday 00:03:34

2460) Archer Martin

Gist:

Work

When a drop of a liquid containing a mixture of various substances is placed on paper, the liquid begins to spread out on the paper. The various substances in the mixture spread at different speeds, however, which gives rise to marks on the paper with different colors. In the 1940s Archer Martin and Richard Synge used this and similar phenomena in gas mixtures, for example, to develop different types of chromatography—methods for separating substances in mixtures and for determining the composition of mixtures.

Summary

A.J.P. Martin (born March 1, 1910, London, England —died July 28, 2002, Llangarron, Herefordshire) was a British biochemist who was awarded (with R.L.M. Synge) the Nobel Prize for Chemistry in 1952 for development of paper partition chromatography, a quick and economical analytical technique permitting extensive advances in chemical, medical, and biological research.

Martin obtained a Ph.D. from the University of Cambridge in 1936 and worked as a research chemist for the Wool Industries Research Association in Leeds from 1938 to 1946. He then became head of biochemical research at the Boots Pure Drug Company, Nottingham, and held the post until 1948, when he was appointed to the staff of the British Medical Research Council. From 1959 to 1970 he was director of Abbotsbury Laboratories, Ltd. Martin also taught at the University of Houston in Texas (1974–79).

Martin and Synge invented paper partition chromatography in 1944. Partition chromatography depends on the partition, or distribution, of each component of a mixture between two immiscible liquids. One of the liquids is held stationary by strong adsorption on the surface of a finely divided solid while the other flows through the interstices of the solid particles. Any substance that preferentially dissolves in the mobile liquid is more rapidly transported in the direction of flow than is a substance that has greater affinity for the stationary liquid. In 1953 Martin and A.T. James helped perfect gas chromatography, the separation of chemical vapours by differential absorption on a porous solid.

Details

Archer John Porter Martin (1 March 1910 – 28 July 2002) was a British chemist who shared the 1952 Nobel Prize in Chemistry for the invention of partition chromatography with Richard Synge.

Early life

Martin's father was a GP. Martin was educated at Bedford School, and Peterhouse, Cambridge.

Career

Working first in the Physical Chemistry Laboratory, he moved to the Dunn Nutritional Laboratory, and in 1938 moved to Wool Industries Research Institution in Leeds. He was head of the biochemistry division of Boots Pure Drug Company from 1946 to 1948, when he joined the Medical Research Council. There, he was appointed head of the physical chemistry division of the National Institute for Medical Research in 1952, and was chemical consultant from 1956 to 1959.

He specialised in biochemistry, in some aspects of vitamins E and B2, and in techniques that laid the foundation for several new types of chromatography. He developed partition chromatography whilst working on the separation of amino acids, and later developed gas-liquid chromatography with Anthony T. James. Amongst many honours, he received his Nobel Prize in 1952.

After his retirement from the University of Sussex, he was visiting professor at both the University of Houston in Texas and the EPFL (École Polytechnique Fédérale de Lausanne) in Switzerland.

He published far fewer papers than the typical Nobel winners—only 70 in all—but his ninth paper contained the work that would eventually win him the Nobel Prize. The University of Houston dropped him from its chemistry faculty in 1979 (when he was 69 years old) because he was not publishing enough.

Awards

Archer Martin shared the 1952 Nobel Prize in Chemistry for the invention of partition chromatography with Richard Synge.

Archer Martin's 1954 paper with Anthony T. James, "Gas-Liquid Chromatography: A Technique for the Analysis and Identification of Volatile Materials" reported the discovery of gas-liquid chromatography. This was performed at the National Institute for Medical Research in Mill Hill, London, which became the Francis Crick Institute in 2016. It was honoured by a Citation for Chemical Breakthrough Award from the Division of History of Chemistry of the American Chemical Society presented in 2016 to the Francis Crick Institute.

Martin was elected a Fellow of the Royal Society in 1950, and made a CBE in 1960.

Personal life

In 1943 he married Judith Bagenal (1918–2006), and together they had two sons and three daughters. In the last years of his life he suffered from Alzheimer's disease.

martin-13082-portrait-medium.jpg

#19 Jokes » Nut Jokes - V » Yesterday 00:03:13

Jai Ganesh
Replies: 0

Q: How do you catch a squirrel for the holidays?
A: Climb a tree and act like nutmeg.
* * *
Q: How do you catch an Irish squirrel?
A: Climb a tree and act like a green pistachio nut.
* * *
Q: How do you catch a European Squirrel?
A: Climb a tree and act like a metric nut.
* * *
Q: How do you catch an English Squirrel?
A: Climb a tree and act like nutty.
* * *
Q: How do you catch a rich squirrel?
A: Climb a tree and act like a cashew.
* * *

#20 Dark Discussions at Cafe Infinity » Comfort Quotes - I » Yesterday 00:02:51

Jai Ganesh
Replies: 0

Comfort Quotes - I

1. The superior man thinks always of virtue; the common man thinks of comfort. - Confucius

2. Just try new things. Don't be afraid. Step out of your comfort zones and soar, all right? - Michelle Obama

3. All strange and terrible events are welcome, but comforts we despise. - Cleopatra

4. Too often we... enjoy the comfort of opinion without the discomfort of thought. - John F. Kennedy

5. If you look for truth, you may find comfort in the end; if you look for comfort you will not get either comfort or truth only soft soap and wishful thinking to begin, and in the end, despair. - C. S. Lewis

6. The game of basketball has been everything to me. My place of refuge, place I've always gone where I needed comfort and peace. It's been the site of intense pain and the most intense feelings of joy and satisfaction. It's a relationship that has evolved over time, given me the greatest respect and love for the game. - Michael Jordan

7. Cure sometimes, treat often, comfort always. - Hippocrates

8. This is no time for ease and comfort. It is time to dare and endure. - Winston Churchill.

#21 This is Cool » Magnesium Hydroxide » 2026-03-15 18:02:43

Jai Ganesh
Replies: 0

Magnesium Hydroxide

Gist

Magnesium hydroxide, with the molecular formula Mg(OH)2, is an inorganic compound used as an antacid to relieve indigestion and a saline laxative to treat occasional constipation. Common side effects include diarrhea, abdominal cramping, and nausea. It works by neutralizing stomach acid and drawing water into the intestines to soften stool.

Magnesium hydroxide is used to treat occasional constipation in children and adults on a short-term basis. Magnesium hydroxide is in a class of medications called saline laxatives. It works by causing water to be retained with the stool.

Summary

Naturally, it occurs in the form of a mineral brucite and is a common compound found in antacids. The chemical formula of Magnesium hydroxide is Mg(OH)2.

Uses of Magnesium hydroxide (Mg(OH)2)

* Magnesium hydroxide is an excellent thermal conductor and poor electrical conductor.
* It is used in suspensions as a laxative or antacid.
* Used as a food additive.
* It is widely used in waste-water treatment.
* Used as a fire retardant.
* It is used in wet plate collodion process as a photographic fixer.
* It is used in gold mining.
* Used in warehouses.

Effects on Health

Flushing or drowsiness are side effects of magnesium hydroxide. Consuming this compound on a daily basis can result in electrolyte disturbances. Excessive use can result in nausea, diarrhoea, and abdominal cramping. Symptoms include watery diarrhoea or gastrointestinal irritation may occur. Poisoning causes hypomagnesemia which includes symptoms such as: vomiting, hypotension, confusion, muscle weakness, cardiac arrhythmias, Cardiac arrest, nausea, flushing, thirst, drowsiness, loss of tendon reflexes, respiratory depression, and coma.

Frequently Asked Questions – FAQs

Q1: What is magnesium hydroxide used for?
A1. Magnesium hydroxide is used to soothe chronic constipation as a laxative. Magnesium hydroxide is also used as an antacid to treat indigestion, heartburn and acidic stomach

Q2: Is Milk of Magnesia the same as magnesium?
A2: Magnesia milk can reduce constipation and improve heartburn and indigestion. Magnesium milk is sometimes referred to as magnesium hydroxide which is its chemical name. Magnesia milk is available to purchase without a prescription over the counter.

Q3: Is magnesium hydroxide a precipitate?
A3: Mg(OH)2 is given partial precipitation with NH4OH by the magnesium ion (Mg2+). Mg(OH)2 is very sparsely soluble in water but is readily soluble in solutions of ammonium salts. Zirconium hydroxide is precipitated by the solutions NH4OH and NaOH.

Q4: What is the pH value of magnesium hydroxide?
A4: The base is magnesium hydroxide. It has approximately a pH of 10. Magnesium hydroxide is usually called magnesium milk.

Q5: Is magnesium hydroxide a weak base?
A5: Unlike lime, it is also much more difficult to treat magnesium hydroxide than it is caustic (NaOH). At neutral pH levels and higher, magnesium hydroxide is nearly insoluble in water. Keeping this in mind, mag has little to no effect on water alkalinity above 7.0 pH.

Details

Magnesium hydroxide is an inorganic compound with the chemical formula Mg(OH)2. It occurs in nature as the mineral brucite. It is a white solid with low solubility in water.

Magnesium hydroxide is a common component of antacids, such as milk of magnesia.

Uses:

Precursor of MgO

Most Mg(OH)2 that is produced industrially, as well as the small amount that is mined, is converted to fused magnesia (MgO). Magnesia is valuable because it is both a poor electrical conductor and an excellent thermal conductor.

Medical

Only a small amount of the magnesium from magnesium hydroxide is usually absorbed by the intestine (unless one is deficient in magnesium). However, magnesium is mainly excreted by the kidneys; so long-term, daily consumption of milk of magnesia by someone suffering from kidney failure could lead in theory to hypermagnesemia. Unabsorbed magnesium is excreted in feces; absorbed magnesium is rapidly excreted in urine.

Applications:

Antacid

As an antacid, magnesium hydroxide is dosed at approximately 0.5–1.5 g in adults and works by simple neutralization, in which the hydroxide ions from the Mg(OH)2 combine with acidic H+ ions (or hydronium ions) produced in the form of hydrochloric acid by parietal cells in the stomach, to produce water.

Laxative

As a laxative, magnesium hydroxide is dosed at 5–10 grams (0.18–0.35 oz), and works in a number of ways. First, Mg2+ is poorly absorbed from the intestinal tract, so it draws water from the surrounding tissue by osmosis. Not only does this increase in water content to soften the feces, it also increases the volume of feces in the intestine (intraluminal volume) which naturally stimulates intestinal motility. Furthermore, Mg2+ ions cause the release of cholecystokinin (CCK), which results in intraluminal accumulation of water and electrolytes, and increased intestinal motility. Some sources claim that the hydroxide ions themselves do not play a significant role in the laxative effects of milk of magnesia, as alkaline solutions (i.e., solutions of hydroxide ions) are not strongly laxative, and non-alkaline Mg2+ solutions, like MgSO4, are equally strong laxatives, mole for mole.

Additional Information

Magnesium hydroxide suspension is a laxative that treats occasional constipation. Constipation occurs when bowel movements become less frequent and stools become difficult to pass. You can take this liquid medication by mouth after measuring each dose in a specially marked spoon or container.

What is this medication?

Magnesium Hydroxide treats occasional constipation. It works by increasing the amount of water your intestine absorbs. This softens the stool, making it easier to have a bowel movement. It also increases pressure, which prompts the muscles in your intestines to move stool. It belongs to a group of medications called laxatives.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

* Bowel, intestinal, or stomach disease
* Change in bowel habits for more than 14 days
* Kidney disease
* Low magnesium diet
* Nausea, vomiting
* Stomach pain or blockage
* An unusual or allergic reaction to magnesium hydroxide, other medications, foods, dyes, or preservatives
* Pregnant or trying to get pregnant
* Breast-feeding

How should I use this medication?

Take this medication by mouth. Follow the directions on the package or prescription label. Shake well before using. Use a specially marked spoon or dropper to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. After taking this medication, drink a full glass of water. Take your medication at regular intervals. Do not take your medication more often than directed.

Talk to your care team about the use of this medication in children. While this medication may be used in children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

* Antibiotics, such as ciprofloxacin or tetracycline
* Digoxin
* Iron supplements
* Thyroid hormones, such as levothyroxine

This medication may affect how well your body can absorb other medications. Talk to your care team about when to take your medications to avoid this problem.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or if they get worse. Do not treat yourself for constipation with this medication for more than 1 week. See your care team if you have black tarry stools, rectal bleeding, or if you feel unusually tired. Do not change to another laxative product without advice.

If you are taking other medications, leave an interval of at least 2 hours before or after taking this medication.

To help reduce constipation, drink several glasses of water a day.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

* Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
* High magnesium level—confusion, drowsiness, facial flushing, redness, sweating, muscle weakness, fast or irregular heartbeat, trouble breathing

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

* Diarrhea
* Stomach cramping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Protect from light and moisture. Throw away any unused medication after the expiration date.

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#22 Science HQ » Endoscopy » 2026-03-15 16:57:49

Jai Ganesh
Replies: 0

Endoscopy

Gist

Endoscopy is a minimally invasive, non-surgical procedure using a flexible tube with a camera (endoscope) to examine internal organs, primarily the digestive tract, in real-time. It is used to diagnose issues like inflammation, ulcers, or tumors and can treat conditions via biopsy or polyp removal.

The main purpose of endoscopy is to visually examine the inside of the body, diagnose problems, monitor conditions, and perform minimally invasive treatments, using a flexible tube with a camera (endoscope) inserted through a natural opening or small incision. It helps doctors investigate symptoms like pain or bleeding, detect diseases such as cancer, inflammation, or ulcers, take tissue samples (biopsies), and even remove polyps or stop bleeding, all without major surgery. 

Summary

An endoscopy is a procedure used in medicine to look inside the body. The endoscopy procedure uses an endoscope to examine the interior of a hollow organ or cavity of the body. Unlike many other medical imaging techniques, endoscopes are inserted directly into the organ.

There are many types of endoscopies. Depending on the site in the body and type of procedure, an endoscopy may be performed by a doctor or a surgeon. During the procedure, a patient may be fully conscious or anaesthetised. Most often, the term endoscopy is used to refer to an examination of the upper part of the gastrointestinal tract, known as an esophagogastroduodenoscopy.

Similar instruments are called borescopes for nonmedical use.

Details

An endoscopy uses a scope that goes inside your body to take pictures or videos of organs and other structures. Healthcare providers use them to screen, diagnose and treat conditions. There are many types of endoscopy that view different organs. The most common types of endoscopy include colonoscopy, upper endoscopy and laparoscopy.

Overview:

What is an endoscopy?

An endoscopy is a procedure done to examine structures inside your body up close. During an endoscopy, a healthcare provider places a long, thin tube (endoscope) inside your body until it reaches the organ or area they need to check. Most endoscopes have a light and special camera at the end. The scope captures images or videos of organs or other body parts. It displays them on a screen your provider sees.

Many endoscopes have special channels inside. Providers can insert operating instruments to remove tissue or perform surgery during an endoscopy.

What are the types of endoscopy?

There are many types of endoscopy procedures. But they all work in the same basic way. A healthcare provider gently inserts a scope into a body opening or small incision. The scope allows them direct access to parts of your body they need to examine or treat.

Key differences include:

* The procedure name. The name usually reflects the organ your provider is checking. For example, a “colonoscopy” is an endoscopy that examines your colon.
* The type of scope. The name usually reflects the organ, too. So the endoscope used for a colonoscopy is called a colonoscope. Endoscopes differ depending on the tasks they help your provider complete. Some are flexible, while others are rigid. Some have channels inside that hold tools that can remove tissue, seal wounds or perform other treatments.

The procedure specifics, including the body parts your provider is examining and where the scope goes in, are different, too.

* Arthroscopy: Scope goes through an incision above your joint to look for damage or conditions like arthritis.
* Bronchoscopy: Scope goes through your mouth or nostril to look at your trachea (windpipe) and lungs.
* Colonoscopy: Scope goes through your math to look at your entire large intestine (colon).
* Cystoscopy: Scope goes through your urethra (the tube that allows pee out of your body) to look at it and your bladder.
* Enteroscopy: Scope goes through your mouth (for upper enteroscopy) or your anal (for lower enteroscopy) to look at your small intestine.
* Esophagogastroduodenoscopy (EGD) or upper endoscopy: Scope goes through your mouth to look at your esophagus, stomach and the upper part of your small intestine.
* Laparoscopy: Scope goes through an incision in your abdomen to look at your abdominal and reproductive organs.
* Laryngoscopy: Scope goes through your mouth or nostril to look at your voice box (larynx).
* Mediastinoscopy: Scope goes through an incision above your breast bone to look at the area between your lungs that includes your heart, esophagus and windpipe (mediastinum).
* Neuroendoscopy: Scope goes through an incision in your skull to look at your brain.
* Proctoscopy (rigid sigmoidoscopy): Scope goes through your anal to look at your anal and rectum.
* Sigmoidoscopy (flexible sigmoidoscopy): Scope goes through your math to look at the*  lower part of your colon (called the sigmoid) and your rectum.
* Thoracoscopy (also called a pleuroscopy): Scope goes through an incision in your chest to look at your lungs and the area around your lungs, including your diaphragm, esophagus and chest walls.
* Ureteroscopy: Scope goes through your urethra to look at the tubes that connect your kidneys to your bladder (ureters).

Advanced endoscopy techniques

Researchers and scientists continually develop new technologies to make endoscopies even less invasive. For example, a capsule endoscopy shows your organs up close without a scope. Instead, you swallow a vitamin-sized capsule with a camera inside. As the capsule travels through your esophagus, stomach and small intestine, it takes pictures that can help diagnose bleeding and tumors in your digestive system.

What does an endoscopy test for?

Healthcare providers use endoscopies to screen for conditions and diagnose diseases. A colonoscopy is probably the most well-known endoscopy used to screen for diseases. It’s used to detect colon cancer. One of the most well-known diagnostic uses of endoscopy is that it allows providers to remove abnormal tissue for lab testing. This is called a biopsy. Biopsies can show if growths are cancerous or noncancerous.

When providers first used endoscopy, they primarily used it to examine organs. Now, they can use endoscopy for many different treatments, such as fixing a bleeding stomach ulcer. In the past, a problem like this could’ve required surgery.

Diseases an endoscopy can detect

An endoscopy can detect diseases that affect your:

* Digestive system, including gastrointestinal diseases, colon polyps and colon cancer.
* Head and neck, including swallowing disorders and laryngitis.
* Joints, including arthritis, tears and dislocations.
* Nervous system, including brain tumors.
* Respiratory system, including lung disease and infections.
* Urinary system, including urinary tract infections (UTIs) and kidney stones.
* Reproductive system, including abnormal uterine bleeding, endometriosis and fertility issues.

Endoscopy treatments

Some endoscopes can be used with instruments that allow providers to:

* Seal wounds.
* Inject medicine.
* Drain fluid.
* Stop internal bleeding.
* Remove damaged tissue or tumors.
* Fix blockages or widen organs that are too narrow.
* Place stents (tiny tubes that open a blocked or damaged organ).
* Perform surgeries.

During a laparoscopy, providers operate on organs through tiny incisions instead of a large opening. This is sometimes called keyhole surgery. It’s much less invasive than traditional surgery. It’s the preferred technique for treating many conditions.

Test Details:

How do I prepare for an endoscopy?

You’ll receive instructions based on the type of endoscopy. You may be asked to:

* Complete required pre-tests and procedures. You may need a urine test (urinalysis) to check for a UTI before procedures involving your urinary tract. You may need a pregnancy test before a hysteroscopy.
* Provide a medical history. Alert your healthcare provider of any conditions and medications or supplements you’re taking.
* Fast. You may need to stop eating or drinking for a certain amount of time before your endoscopy. Or, you may need to limit yourself to only certain types of food and drink.
* Cleanse your bowels. You may be asked to complete a bowel prep, which involves flushing the feces (poop) out of your intestines. Colonoscopies, enteroscopies and other procedures involving your lower digestive tract involve bowel prep.
* Stop taking certain medicines. You may need to stop taking blood thinners like warfarin (Coumadin® or Jantoven®) and aspirin. You may need to switch prescription medicines briefly before the procedure. Follow your provider’s guidance.
* Stop smoking. You may need to stop smoking and using tobacco products before your procedure.
* Arrange for someone to drive you home. You won’t be able to drive yourself if you receive sedation or anesthesia for your procedure and go home the same day. Most people need to arrange for a driver.

What should I expect during an endoscopy?

An endoscopy typically takes 30 minutes to two hours, depending on the procedure type. Most people go home on the day of their endoscopy, but some endoscopies require an overnight hospital stay.

Providers use moderate sedation for most endoscopies so that you’re asleep and pain-free during the procedure. General anesthesia (which involves intubation, or placement of a breathing tube) is necessary in a small percentage of cases. Some people may instead get local anesthesia and a sedative. Local anesthesia numbs a particular area instead of putting you to sleep completely. Sedatives help you relax.

Once you’re completely relaxed or asleep, the provider gently inserts the scope until it reaches the area they want to examine. They’ll adjust the scope to display the correct organs or structures on the screen. They’ll note irregular areas and remove tissue or provide treatment if needed.

They’ll close any incisions.

How painful is an endoscopy?

The anesthesia and sedatives prevent you from experiencing pain during the procedure. With some procedures, like a colonoscopy, you may feel pressure when the scope goes in, but the feeling passes quickly.

Additional Information

Endoscopy is a procedure that lets your doctor look inside your body. It uses an instrument called an endoscope, or scope for short. Scopes have a tiny camera attached to a long, thin tube. The doctor moves it through a body passageway or opening to see inside an organ. Sometimes scopes are used for surgery, such as for removing polyps from the colon.

There are many different kinds of endoscopy. Here are the names of some of them and where they look.:

Arthroscopy: joints
Bronchoscopy: lungs
Colonoscopy and sigmoidoscopy: large intestine
Cystoscopy and ureteroscopy: urinary system
Laparoscopy: abdomen or pelvis
Upper gastrointestinal endoscopy: esophagus and stomach

What is an endoscopy?

A doctor or specialist nurse, called an endoscopist does the test. The endoscopist uses these to look inside different parts of the body.

The endoscopist can use the camera to take photographs or videos of the areas they are looking at. They can also pass fine surgical instruments through the endoscopes.

The name of the test you have will depend on which part of the body the endoscopist is looking at.

Why do I need an endoscopy?

You might have an endoscopy to help find out what is causing your symptoms. During this test the endoscopist can also take a sample () of any abnormal looking tissue through the endoscope.

Sometimes you might have an endoscopy for treatment. For example, to control bleeding or to put in a .

You are most likely to have an endoscopy to look at the inside of your:

* food pipe (oesophagus)
* stomach
* duodenum, which is the first part of the small bowel that attaches to the stomach

This test is called a gastroscopy or oesophago gastric duodenoscopy (OGD).

You may have this test if you have symptoms such as:

* abnormal bleeding
* indigestion
* low levels of iron (iron deficiency anaemia)
* difficulty swallowing

If you have  you'll have regular gastroscopies to check for any changes to cells in the lining of your food pipe. The endoscopist looks down the endoscope to see if there are any abnormal looking areas. If any are found they can take biopsies through the endoscope.

endoscopic-procedure-illustration.png?h=400&iar=0&mh=400&mw=670&w=582&hash=2AB34F34481652BF9F6C6798B4F749C7

#23 Re: Jai Ganesh's Puzzles » General Quiz » 2026-03-15 16:08:34

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