Collagen

Jai Ganesh · 2024-03-18 18:39:11

Collagen

Gist

Collagen is the most abundant protein in the body. Its fiber-like structure is used to make connective tissue. Like the name implies, this type of tissue connects other tissues and is a major component of bone, skin, muscles, tendons, and cartilage.

Summary

Collagen is any of a group of proteins that are components of whitish, rather inelastic fibres of great tensile strength present in tendon and ligament and in the connective tissue layer of the skin—dermis—and in dentin and cartilage. Collagenous fibres occur in bundles up to several hundred microns wide, and the individual fibres can be separated into fine fibrils; the fibrils, furthermore, consist of even finer filaments with a periodic banded structure.

Collagen is a scleroprotein, being one of a family of proteins marked by low solubility in water. Collagen is especially rich in the amino acid glycine, and it is the only protein known to contain a substantial proportion of hydroxyproline. Upon exposure to boiling water, collagen is converted to gelatin.

Details

Collagen is a type of protein. Certain foods, such as animal skin and ligaments, are rich in collagen. Collagen is also available as a supplement.

Many people hoping to support the health of their skin, joints, and hair pop collagen supplements daily or add collagen powder to their morning coffee, tea, or smoothie.

Even though the use of collagen supplements and other collagen products is on the rise, most people don’t know what collagen actually is or what it does in the body.

This article tells you everything you need to know about collagen, including what it is, what it does in your body, and whether collagen supplements are worth it.

What is collagen and why is it important?

Collagen is a type of protein. In fact, it’s the most abundant structural protein in animals. A structural protein is one that makes up the structure or framework of your cells and tissues.

There are 28 known types of collagen, with type I collagen accounting for 90% of the collagen in the human body.

Collagen is composed mainly of the amino acids glycine, proline, and hydroxyproline. These amino acids form three strands, which make up the triple-helix structure characteristic of collagen.

Collagen is found in connective tissue, skin, tendons, bones, and cartilage. It provides structural support to tissues and plays important roles in cellular processes, including :

* tissue repair
* immune response
* cellular communication
* cellular migration, a process necessary for tissue maintenance

Connective tissue cells called fibroblasts produce and maintain collagen. As people grow older, their collagen becomes fragmented, fibroblast function becomes impaired, and collagen production slows.

These changes, along with the loss of another key structural protein called elastin, lead to signs of aging such as sagging skin and wrinkles.

Collagen uses

Your body naturally produces collagen, and you can consume it through dietary sources such as chicken skin and fish skin as well as collagen supplements.

Oral and topical collagen products like supplements and face creams are popular for treating signs of aging such as wrinkles, loss of skin hydration, and joint pain.

You can buy collagen in powder, capsule, and liquid form.

You can take it as a supplement or add it to beverages — both hot and cold — and foods such as oatmeal, yogurt, and energy balls.

Healthcare professionals also use collagen and collagen-based materials in the medical field, including in treating wounds, burns, and diabetic ulcers.

Additionally, cosmetics companies use collagen in products like moisturizers and serums because of its moisturizing and humectant properties.

SUMMARY

Your body makes collagen naturally. Collagen is found in connective tissue, skin, tendon, bone, and cartilage and has many functions. It’s also present in some foods, and you can take it as a supplement.

What causes collagen loss?

As you age, your collagen production naturally declines. Additionally, collagen becomes fragmented and more loosely distributed.

These changes lead to the characteristic signs of aging, such as wrinkles and dry, sagging skin. The integrity of the collagen found in the skeletal system decreases with age as well, leading to reductions in bone strength.

While collagen loss and damage as you age are inevitable, certain dietary and lifestyle factors can accelerate this process.

For example, smoking cigarettes is known to degrade collagen and cause skin aging, wrinkles, and loss of elasticity.

Excessive drinking has also been shown to accelerate skin aging by reducing collagen production and damaging skin repair mechanisms.

Additionally, following a diet high in added sugar and ultra-processed foods can lead to premature aging by contributing to a process called glycation, which reduces collagen turnover and interferes with collagen’s ability to interact with surrounding cells and proteins.

Excessive sun exposure degrades collagen production as well, so wearing sunscreen and avoiding excessive sun exposure can help prevent signs of premature skin aging.

SUMMARY

Age-related collagen loss is unavoidable, but dietary and lifestyle factors such as smoking and excessive alcohol intake can speed up this process.

What foods are rich in collagen?

Collagen is found in all animals, and it’s concentrated in some parts of an animal, such as skin and joints.

Here are few examples of collagen-rich foods:

* bones, skin, and ligaments of animals, such as chicken skin and pig knuckle
* certain types of seafood, such as fish skin and jellyfish
* products made from animal parts such as bones and ligaments, including bone broth

Because your body naturally produces collagen from amino acids, you can support collagen production by ensuring that you’re eating adequate amounts of protein from foods like poultry, fish, beans, and eggs.

In addition to amino acids, your body needs other dietary components for collagen production and maintenance.

For example, vitamin C is necessary for collagen synthesis, so having low or deficient levels of vitamin C can lead to impaired collagen production.

Therefore, consuming plenty of vitamin C-rich foods can help support healthy collagen production. For example, try citrus fruits, peppers, greens, and berries.

What’s more, consuming a diet high in beneficial plant compounds could also help improve skin health by reducing inflammation and protecting against collagen degradation.

SUMMARY

Certain foods, such as animal skin and ligaments, are rich in collagen. A collagen-supportive diet should include protein-rich foods as well as fruits and vegetables, which are rich in vitamin C and other antioxidant and anti-inflammatory compounds.

What are the benefits of taking collagen?

Studies have shown that taking collagen supplements may offer a few benefits.

Potential skin benefits

One of the most popular uses of collagen supplements is to support skin health. Research suggests that taking collagen supplements may improve certain aspects of skin health and appearance.

A review of 19 studies that included 1,125 participants (95% women) between the ages of 20 and 70 found that taking hydrolyzed collagen improved skin hydration, elasticity, and wrinkles compared with placebo treatments.

Hydrolyzed collagen is a common type of collagen used in supplements that is created using a process called hydrolysis. This process breaks down the protein into smaller pieces, making it easier for the body to absorb.

A number of studies have shown that taking collagen supplements may improve skin hydration and elasticity and reduce the appearance of wrinkles.

However, keep in mind that many of these studies were funded by companies that manufacture collagen products, which could have influenced the study results.

The doses of collagen shown to be effective for improving skin health in research studies vary, though most studies have used 2.5–15 grams per day for 8 weeks or longer.

Potential benefits for bones

In addition to improving some aspects of skin health and appearance, collagen supplements may offer a few other benefits.

One study looked at the effects of taking collagen supplements in 102 women in postmenopause who had reduced bone mineral density (BMD).

Those who took 5 grams of collagen peptides per day for 1 year had significant increases in BMD in their spine and femur (a bone in the lower leg) compared with participants who took a placebo.

A follow-up study in 31 of these women found that taking 5 grams of collagen daily for a total of 4 years was associated with a progressive increase in BMD.

The researchers found that participants’ BMD increased by 5.79–8.16% in the spine and by 1.23–4.21% in the femur during the follow-up period.

These findings suggest that taking collagen supplements long-term may help increase bone mineral density in people in postmenopause, who are at a greater risk of developing osteopenia and osteoporosis.

What’s more, one review article concluded that taking oral collagen supplements reduced participants’ symptoms related to osteoarthritis, including stiffness.

Collagen supplements may provide other health benefits as well, such as improving body composition in certain populations when combined with resistance training.

It’s important to note that studies observed these beneficial effects of taking collagen mainly in older women with low bone mineral density.

Therefore, collagen supplements may not have the same effects in other populations, such as men, those who are younger, or those who don’t have low bone mineral density.

Additional Information

Collagen is the main structural protein in the extracellular matrix found in the body's various connective tissues. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content. Collagen consists of amino acids bound together to form a triple helix of elongated fibril[ known as a collagen helix. It is mostly found in connective tissue such as cartilage, bones, tendons, ligaments, and skin. Vitamin C is vital for collagen synthesis, and Vitamin E improves the production of collagen.

Depending upon the degree of mineralization, collagen tissues may be rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). Collagen is also abundant in corneas, blood vessels, the gut, intervertebral discs, and the dentin in teeth. In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue and accounts for 6% of the weight of the skeletal muscle tissue. The fibroblast is the most common cell that creates collagen. Gelatin, which is used in food and industry, is collagen that has been irreversibly hydrolyzed using heat, basic solutions or weak acids.

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#1 2024-03-18 18:39:11

Collagen

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